Dr. Bharat Aggarwal started his career with a start-up company, Genentech, where he worked for almost ten years and his work lead to the discovery of TNF-a and TNF-b; and identification of their receptors. Humira, an antibody against TNF-a is a blockbuster biologic drug with annual revenue of more than $10 billion USD. . In 1989, when Dr. Aggarwal joined M. D. Anderson, his group focused on the “Role of Inflammatory Pathways Mediated through TNFs, RANK, TRAIL, CXCR4, NF-kappaB, and STAT3, for the Prevention and Therapy of Cancer and other Chronic Diseases”.
Dr. Sudhir Gupta is a Professor of Medicine, Pathology & Laboratory Medicine, and Microbiology & Molecular Genetics, Chief of the Division of Basic and Clinical Immunology, and the Director of the Jeffrey Modell Diagnostic Center in Primary Immunodeficiencies at the University of California, Irvine. Dr. Gupta has served on a number of committees including the National Institutes of Health, the U.S. Food and Drug Administration, and the World Health Organization.